Bishop Manuel de São Galdino was a member of the Franciscan Order of Friars Minor. He was appointed Bishop of Macao in 1802 and took his office in the following year. During his two years of service in Macao, he focused on reforming the undersirable practice of the Churhc, instituted regulation for the seminary ad concelled all superstitious religious procession. In 1804 he was nominated the Coadjutor Bishop of the Archdiocese of Goa in India, being the right successor to the seat. He arrived at Goa in 1806 ad took up the service of Archbishop in 1812. He died in his term of office in 1831.