Father Antonio Joaquin de Medeiros was in Macao as early as 1872. He had been the rector of the seminary and the vicar general as well as being responsible for the Episcopal affairs of Timor. Later in 1884 he was appointed as Bishop of Macao. In 1885 he founded the Holy Infant Foundling Hospital. In 1886 he drafted a fraternal agreement between Portugal and Vatican. In 1889, the Cannosian sisters took over the management of Santa Rosa de Lima College. In 1890 he obtained approval to invite the Jesuit missionaries to come to Macao to take charge of the St. Joseph's Seminary. In 1897 he died during his visit to Timor.